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US 9,283,195 B2Granted
Methods used to characterize and treat glioblastoma
AssigneeThe Translational Genomics Research Institute
InventorNhan Tran
Life of this patent
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Abstract
The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as well as therapeutic outcome.
Claims18
A method of treating a patient with glioblastoma, the method comprising the steps of:
- (a) sensitizing the patient to a treatment by reducing an expression level of a marker selected from the group consisting of SEQ ID NO:
- 1 and SEQ ID NO. 2;
- and
- (b) administering a therapeutically effective amount of the treatment to the patient.
1 more element
A method of characterizing a glioblastoma tumor as invasive and sensitizing the invasive glioblastoma tumor for treatment, the method comprising the steps of:
- (a) adding a first reagent capable of binding to a marker selected from the group consisting of SEQ ID NO. 1 and SEQ ID NO. 2 to a mixture comprising a sample of the glioblastoma tumor;
- (b) subjecting the mixture to conditions that allow detection of binding of the reagent to the marker;
- (c) classifying the glioblastoma tumor as invasive when the binding of the reagent to the marker is increased compared to a control sample;
- and
- (d) reducing an expression level of the marker to sensitize the invasive glioblastoma tumor to a treatment.
2 more elements
A method of treating a patient with invasive glioblastoma, the method comprising the steps of:
- (a) sensitizing the patient to a treatment by reducing an expression level of at least one of the following:
- a marker selected from the group consisting of SEQ ID NO:
- 1 and SEQ ID NO. 2 and Proline-rich tyrosine kinase 2 (Pyk2);
- and
- (b) administering a therapeutically effective amount of the treatment to the patient.
2 more elements
Dependencies are inferred from the claim text.