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US 9,283,193 B2Granted
Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
AssigneeMannKind Corporation
InventorsKeith A. Oberg, Joseph Sulner, Marshall L. Grant
Life of this patent
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Abstract
Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.
Claims10
A microparticle comprising a fumaryl diketopiperazine (FDKP) core microparticle and an insulin coating, wherein the insulin coating is about 9% to about 12% of the total weight of the microparticle.
Dependencies are inferred from the claim text.