Delayed prolonged drug delivery
AssigneeUniversity of Strathclyde
InventorsAlexander Mullen, Howard Stevens, Sarah Eccleston
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Abstract
In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released in a prolonged manner at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released whilst a subject is sleeping, shortly before waking and continues to administer the drug during the early waking hours. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for a delayed, followed by a prolonged release of drug.
Claims24
A press-coated tablet formulation for a delayed, followed by a prolonged release of an active agent, the press-coated tablet formulation comprising:
- (a) a core comprising the active agent together with a wax and optionally one or more fillers;
- and
- (b) a delayed release layer surrounding the core and comprising a wax and a low substituted hydroxypropyl cellulose in a ratio of 20:80 to 50:50 w/w;
- wherein the delayed release layer delays release of the active agent within the core for between 2-8 hours after administration of the press-coated tablet formulation to a subject and thereafter a prolonged release of the active agent from the core occurs, such that the active agent in the core is continuously released over a period of 2 up to 8 hours and wherein the low substituted hydroxypropyl cellulose is micronised with a mean particle diameter of 20 μm and has a molecular weight of 115,000 and a hydroxypropyl content of 8%.
Dependencies are inferred from the claim text.