Liposomal curcumin for treatment of cancer
AssigneeBoard of Regents, The University of Texas System
InventorsRazelle Kurzrock, Lan Li, Kapil Mehta, Bharat Bhushan Aggarwal
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Abstract
The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system. Suitable colloidal drug delivery systems also include nanoparticles, nanocapsules, microparticles or block copolymer micelles. The colloidal drug delivery system encapsulating curcumin or a curcumin analogue is administered parenterally in a pharmaceutically acceptable carrier.
Claims8
A method for treating melanoma, pancreatic and breast carcinoma cells in a mammalian subject, comprising:
- a) formulating a PEG containing stealth liposome encapsulating at least one of a curcumin or a curcumin analogue in an amount sufficient to treat a pancreatic cancer, breast cancer or a melanoma;
- and
- b) administering the PEG containing stealth liposome to a mammalian subject in a pharmaceutically acceptable carrier, wherein the encapsulated curcumin or curcumin analogue have a reduced toxicity, wherein the liposome comprises a lipid formulation selected from:
- DMPC;
- DMPC:Chol 9:1;
- DMPC:DMPG 9:1;
- DMPC:Chol:DMPG 8:1:1;
- DPPC:DMPG 9:1;
- DPPC:Chol:DMPG 8:1:1;
- DMPC:DMPE-PEG-2000 95:5;
- DMPC:Chol:DMPE-PEG-2000 90:10:05;
- DMPC:DSPE-PEG-2000 95:5;
- DMPC:Chol:DSPE-PEG-2000 90:10:05;
- DMPC/DMPG 7:3;
- DPPC/DMPG 7:3;
- DPPC/DMPG 9:1;
- or DOPC [10:1].
A composition for treating melanoma, pancreatic and breast carcinoma cells in a patient or other mammalian subject comprising curcumin or a curcumin analogue in an amount sufficient to treat the pancreatic cancer, a breast cancer or the melanoma, wherein the curcumin or curcumin analogue is encapsulated in a PEG containing stealth liposome drug delivery system, wherein the encapsulated curcumin or curcumin analogue have a reduced toxicity, and wherein the liposome comprises a lipid formulation selected from:
- DMPC;
- DMPC:Chol 9:1;
- DMPC:DMPG 9:1;
- DMPC:Chol:DMPG 8:1:1;
- DPPC:DMPG 9:1;
- DPPC:Chol:DMPG 8:1:1;
- DMPC:DMPE-PEG-2000 95:5;
- DMPC:Chol:DMPE-PEG-2000 90:10:05;
- DMPC:DSPE-PEG-2000 95:5;
- DMPC:Chol:DSPE-PEG-2000 90:10:05;
- DMPC/DMPG 7:3;
- DPPC/DMPG 7:3;
- DPPC/DMPG 9:1;
- or DOPC [10:1].
Dependencies are inferred from the claim text.