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US 9,283,097 B2Granted
Bioabsorbable scaffold with particles providing delayed acceleration of degradation
AssigneeAbbott Cardiovascular Systems Inc.
InventorsYunbing Wang, James Oberhauser
Life of this patent
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Abstract
Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. A bioabsorbable scaffold having a plurality of particles incorporated into the scaffolding that accelerate the absorption of the scaffolding after an induction time during degradation is disclosed.
Claims5
A method of making a bioabsorbable poly(L-lactide) (PLLA) stent scaffolding comprising:
- making a plurality of particles having surface eroding polymer encapsulating L-lactide monomer that is not polymerized or chemically bound to other molecules, wherein the L-lactide monomer is initially shielded by being encapsulated by the surface-eroding polymer that erodes away after a selected induction time to allow for accelerated degradation of the PLLA scaffolding;
- and
- making the stent scaffolding from PLLA resin with the plurality of particles dispersed throughout the PLLA of the scaffolding, wherein when the scaffolding is exposed to moisture the surface-eroding polymer prevents contact of the L-lactide with moisture for the selected induction time and after the selected induction time the L-lactide accelerates degradation of the PLLA of the scaffolding.
Dependencies are inferred from the claim text.