Carotid body ablation via directed energy
AssigneeCibiem, Inc.
InventorsMark Gelfand, Charles Lennox, Ary Chernomorsky, Howard Levin, Veijo T. Suorsa, Kenneth M. Martin, Yegor D. Sinelnikov
Life of this patent
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Abstract
Methods and devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation.
Claims46
A method of carotid septum ablation to treat at least one of heart failure and hypertension, comprising endovascularly positioning a distal region of a catheter within an internal jugular vein or one of its tributaries and proximate a carotid septum, the distal region comprising an ultrasound ablation transducer;
- targeting carotid septum tissue for ablation with ablative ultrasound energy without targeting a carotid sinus by rotating the ultrasound ablation transducer within the jugular vein to aim the ablative ultrasound energy towards the carotid septum tissue and away from the carotid sinus;
- and
- directing the ultrasound ablation energy towards the carotid septum and away from the carotid sinus to ablate the carotid septum tissue with ablative ultrasound energy, to treat at least one of heart failure and hypertension.
A method of carotid septum ablation to treat at least one of heart failure and hypertension, comprising:
- endovascularly positioning a distal region of a catheter within an internal jugular vein or one of its tributaries and proximate a carotid septum, the distal region comprising an ultrasound ablation transducer;
- targeting carotid septum tissue for ablation with ablative ultrasound energy without targeting a carotid sinus by reconfiguring the catheter to manipulate the wall of the jugular vein or one of its tributaries with the catheter;
- and
- ablating the carotid septum tissue with ablative ultrasound energy to treat at least one of heart failure and hypertension.
A method of carotid septum ablation to treat at least one of heart failure and hypertension, comprising:
- endovascularly positioning a distal region of a catheter within an internal jugular vein or one of its tributaries and proximate a carotid septum, the distal region comprising an ultrasound ablation transducer;
- targeting carotid septum tissue for ablation with ablative ultrasound energy without targeting tissue beyond a medial boundary of the septum, wherein targeting carotid septum tissue for ablation with ablative ultrasound energy without targeting tissue beyond a medial boundary of the septum comprises controlling the ablative ultrasound energy delivery parameters;
- and
- ablating the carotid septum tissue with ablative ultrasound energy using the ultrasound ablation transducer to treat at least one of heart failure and hypertension.
Dependencies are inferred from the claim text.