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US 9,282,931 B2Granted
Methods for tissue analysis
AssigneeThe General Hospital Corporation
InventorsGuillermo J. Tearney, Brett E. Bouma
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Abstract
The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.
Claims17
A method of analyzing a tissue structure, comprising:
- illuminating the tissue structure with at least one of a coherent light or a partially coherent light from a light source onto the tissue structure;
- receiving a further light reflected from the tissue structure and forming a series of speckle patterns based on the further light;
- and
- obtaining speckle pattern data from the series of speckle patterns at time intervals sufficient to measure a microscopic motion within the tissue structure or within a tissue adjacent to the structure;
- and
- assessing the tissue structure by analyzing spatial characteristics of the speckle pattern data, and determining at least one of structural characteristics or biomechanical characteristics of the tissue structure which is in vivo tissue based on the assessment of the tissue structure.
3 more elements
A method for analyzing tissue, comprising:
- illuminating the tissue with at least one of a coherent light or a partially coherent light from a light source onto the tissue;
- receiving a further light reflected from the tissue and form a series of speckle patterns based on the further light;
- and
- analyzing changes in the speckle patterns at time intervals sufficient to measure changes caused by a microscopic motion of objects within the tissue which is in vivo tissue.
1 more element
Dependencies are inferred from the claim text.