Methods and systems for optimizing lesion placement to minimize and treat cardiac fibrillation

A system for optimizing lesion placement to treat cardiac fibrillation in a patient, comprising:

• a processing unit configured to process a map of one or more measurements indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across a cardiac tissue substrate in the patient's heart in response to electrical activity in the cardiac tissue substrate, said map being registered onto a representation of the patient's heart, to identify at least one region of the cardiac tissue substrate having a number of electrical circuit cores that is higher than a predetermined density threshold, to generate a first sample set of lesions, said first sample set of lesions being registered onto the map, to calculate a first total length of the first sample set of lesions by aggregating the length of each lesion in said first sample set of lesions, to compare the first total length to a predetermined length threshold, to determine a level of optimization of the first sample set of lesions, wherein one or more optimization criteria are indicative of the level to which the sample set can at least one of minimize and terminate cardiac fibrillation and comprise at least one of the predetermined length threshold and the predetermined density threshold, to generate at least one successive sample sets of lesions if the one or more optimization criteria are not met by a previous sample sets of lesions, and to repeat the steps of calculating a total length of each successive sample set of lesions, comparing the total length of each successive sample set of lesions to the predetermined length threshold, and determining a level of optimization of each successive sample set of lesions until the one or more optimization criteria are met;
• and
• a storage unit to store data and executable instructions to be used by the processing unit.