Multiwell microelectrode array with optical stimulation
AssigneeAxion BioSystems, Inc.
InventorsIsaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
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Abstract
An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
Claims28
An electro-optical stimulation and recording system, comprising:
- a substrate;
- a plurality of wells coupled to the substrate;
- at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well;
- at least one light-emitting element set corresponding to the respective one of the plurality of wells and configured to deliver optical stimulation to at least a portion of the respective well.
A method for large-scale in vitro testing of cell cultures, the method comprising:
- providing a control signal for causing a light-emitting element to emit light in an illumination pattern, the light-emitting element disposed proximate a well of a multiwell plate;
- detecting, via an electrode disposed proximate the well, a signal associated with at least a portion of the well;
- analyzing the detected signal;
- and
- outputting information indicative of the analysis.
An electro-optical stimulation and recording system, comprising:
- an electrode set disposed proximate a first well and comprising a first electrode configured to collect an electric signal associated with at least a portion of the first well;
- a first light-emitting element set configured to deliver optical stimulation to at least a portion of the first well;
- and
- a processor, configured to:
- provide a first control signal for causing a first light-emitting element to emit light at a first illumination pattern;
- and
- detect, via the first electrode, a first signal associated with at least a portion of the first well.
Dependencies are inferred from the claim text.