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US 9,278,156 B2Granted
Bioresorbable wound dressing
AssigneesBiopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH, Carl Freudenberg KG
InventorsFrank Plöger, Denis Reibel, Dirk Grafahrend, Daniel Neumüller
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Abstract
The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. Furthermore, the invention provides wound dressings, pads or implants comprising the novel non-woven fabrics.
Claims17
A non-woven fabric comprising:
- fibres of a fibre raw material comprising bioresorbable and/or biocompatible polymers, the fibres including at least one biologically active substance, which is distributed in the fibres,
- wherein the biologically active substance is a GDF-5-related protein,
- wherein the GDF-5-related protein comprises a cystine-knot-domain with an amino acid identity of at least 60% to the 102 aa-cystine-knot-domain of human GDF-5 according to amino acids 400-501 of SEQ ID NO:2, and
- wherein the GDF-5-related protein which is distributed in the fibres is incorporated into the fibre raw material before forming of the fibres.
1 more element
Dependencies are inferred from the claim text.