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US 9,278,100 B2Granted
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
AssigneePharmacyclics, Inc.
InventorsLee Honigberg, Erik Verner, Joseph Buggy, David Loury, Wei Chen
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Abstract
Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
Claims2
A method for treating a solid tumor in an individual comprising administering to the individual in need thereof:
- (a) an anti-cancer agent;
- and
- (b) an irreversible covalent inhibitor of Bruton's tyrosine kinase (Btk) having the structure:
- or a pharmaceutically acceptable salt thereof,
- wherein the solid tumor is non-small cell lung cancer.
2 more elements
Dependencies are inferred from the claim text.