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US 9,273,284 B2Granted
Method for generating potent dendritic cells
AssigneeThe Regents of the University of California
InventorsRobert Lazarus Modlin, Mirjam Schenk
Life of this patent
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Abstract
Highly potent dendritic cells are generated in vivo or ex vivo by exposing precursor cells to an effective dose of IL-32.
Claims6
A method of inducing dendritic cell differentiation from a mammalian precursor cell, the method comprising:
- contacting a population of human monocytes with an effective dose of IL-32, for a period of time sufficient to induce differentiation of the precursor cells into dendritic cells wherein the contacting is performed ex vivo;
- and
- isolating CD1b positive dendritic cells from said population.
Dependencies are inferred from the claim text.