Hydroxy acid ester compound of substituted phenol, preparation method and medical use thereof
AssigneeWest China Hospital, Sichuan University
InventorsWensheng Zhang, Jun Yang, Jin Liu
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Abstract
Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C1-4 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.
Claims16
A hydroxy acid ester compound of substituted phenol represented by the following structure formula (I):
- wherein Y is a straight saturated carbon chain of —CH2—CH2or —CH2—CH2—CH2—, the straight saturated carbon chain optionally substituted with methyl, ethyl, cyclopropyl, hydroxy, sulfhydryl, amino, or a substituted amino group.
Dependencies are inferred from the claim text.