Compositions and methods for treating nephropathy
AssigneeComplexa, Inc.
InventorDaniel Joseph Cushing
Life of this patent
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Abstract
Activated fatty acids, pharmaceutical composition compositions including activated fatty acids, methods for using activated fatty acids to treat nephropathy, and methods for preparing activated fatty acids are provided herein.
Claims28
A method for treating contrast agent-induced nephropathy in a subject comprising administering a therapeutically effective amount of an activated fatty acid, a prodrug, or a metabolite thereof, wherein the activated fatty acid is an unsaturated or polyunsaturated fatty acid having an aliphatic chain comprised of 4 to 25 carbons and one or more electron withdrawing groups associated with at least one carbon-carbon double bond, the one or more electron withdrawing groups being selected from the group consisting of aldehyde (—COH), acyl (—COR), carbonyl (—CO), carboxylic acid (—COOR), ester (—COOR), halides (—Cl, —F, —Br, —I), fluoromethyl (—CFn, n=I-3), allyl fluoride (—CH═CHCH2F), cyano (—CN), sulfoxide (—SOR), sulfonyl (—S02R), sulfonic acid (—S03H), 1°, 2° and 3° ammonium (—NR3 +), or nitro (—N02), wherein R is a hydrogen, methyl or C2-C6 alkyl, further comprising administering one or more secondary agents selected from the group consisting of cytoprotective agents, angiotensin II inhibitors, angiotensin converting enzyme (ACE) inhibitors, and combinations thereof.
A method for treating contrast agent-induced nephropathy in a subject comprising administering a therapeutically effective amount of an activated fatty acid, a prodrug, or a metabolite thereof, wherein the activated fatty acid is an unsaturated or polyunsaturated fatty acid having an aliphatic chain comprised of 4 to 25 carbons and one or more electron withdrawing groups associated with at least one carbon-carbon double bond, the one or more electron withdrawing groups being selected from the group consisting of aldehyde (—COH), acyl (—COR), carbonyl (—CO), carboxylic acid (—COOR), ester (—COOR), halides (—Cl, —F, —Br, —I), fluoromethyl (—CFn, n=1-3), allyl fluoride (—CH═CHCH2F), cyano (—CN), sulfoxide (—SOR), sulfonyl (—SO2R), sulfonic acid (—SO3H), 1 °, 2° and 3° ammonium (—NR3+), or nitro (—NO2), wherein R is a hydrogen, methyl or C2-C6 alkyl, wherein the nephropathy comprises hypercalcemia, hyperuricemia, lysozymuria, disseminated intravascular coagulopathy, immune complex mediated glomerulopathy, paraprotein-related nephropathy, amyloidosis, and urinary tract infections, or any combinations thereof.
Dependencies are inferred from the claim text.