Back to results
US 9,271,934 B2Granted
Water dispersible glyceryl monooleate magnetic nanoparticle formulation
AssigneeInstitute of Life Sciences
InventorsSanjeeb Kumar Sahoo, Fahima Dilnawaz, Abhalami Singh Singh
Life of this patent
Estimating the term…
Abstract
The present invention is an aqueous dispersible magnetic nanoparticle formulation with a high drug loading capacity used for sustained drug delivery. The formulated magnetic nanoparticles are composed of an iron oxide core coated with a long chain polymer, which provides aqueous dispersibility without the use of surfactant. A method is developed for the functionalization of magnetic nanoparticles for use in biomedical field.
Claims8
A method for preparing glyceryl monooleate (GMO) magnetic nanoparticles (MNPs) formulation comprising:
- heating a mixture of Fe (III) and Fe (II) with constant stirring under N2 atmosphere;
- adding ammonium hydroxide to the said mixture;
- adding glyceryl monooleate (GMO) to the suspension drop wise;
- subjecting the mixture to the step of stirring under N2 atmosphere;
- washing the formulation several times with a solvent mixture comprising ethyl acetate:
- acetone (70:30 v/v) to wash excess glyceryl monooleate (GMO);
- and
- subjecting the washed formulation to lyophilization to yield powder form.
5 more elements
Dependencies are inferred from the claim text.