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US 9,267,867 B2Granted
Method and apparatus for treatment enhancement in acoustic processing of samples
AssigneeCovaris, Inc.
InventorJames A. Laugharn, Jr.
Life of this patent
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Abstract
Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using an energy director positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
Claims17
An acoustic treatment device, comprising:
- a vessel arranged to hold a sample that includes a liquid, the vessel capable of holding a sample volume of about 300 microliters or less;
- and
- a cap constructed and arranged to engage with the vessel and cover an opening of the vessel, the cap including a split septum;
- and
- an energy director including a rod attached to and depending from the cap and configured to be positioned in a portion of the sample when the cap is engaged with the opening, the energy director having a hydrophobic or hydrophilic surface with crevices, wherein the surface with crevices is arranged to be located in the sample to disrupt material of the sample on or near the surface with crevices by controlling interaction between acoustic energy having a frequency of between about 100 kilohertz and about 100 megahertz and a focal zone with a width of less than about 2 centimeters and the sample when the acoustic energy is emitted remotely from the vessel and applied to the vessel.
2 more elements
Dependencies are inferred from the claim text.