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US 9,266,946 B2Granted
Targeting ABCB5 for cancer therapy
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMarkus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
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Abstract
The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
Claims13
A method for treating a subject, comprising
- systemically administering an isolated antibody that selectively binds to ABCB5 to a subject having cancer in an effective amount to treat the cancer, wherein the isolated antibody is not co-administered with a chemotherapeutic agent.
Dependencies are inferred from the claim text.