Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof

A pharmaceutical product comprising an allergen extract or an allergoid thereof, which comprises:

• a) an extract of Der p mite bodies, wherein the extract of Der p mite bodies is prepared from one fraction or combined fraction(s) of mite cultures said fraction(s) comprising more than 80% v/v Der p mite bodies,
• b) an extract of Der f mite bodies, wherein the extract of Der f mite bodies is prepared from one fraction or combined fraction(s) of mite cultures said fractions comprising more than 80% v/v Der f mite bodies,
• c) an extract of Der p faecal particles, wherein the extract of Der p faecal particles is prepared from one fraction or combined fraction(s) of mite cultures said fraction(s) comprising more than 80% v/v Der p faecal particles, and
• d) an extract of Der f faecal particles, wherein the extract of Der f faecal particles is prepared from one fraction or combined fraction(s) of mite cultures said fraction(s) comprising more than 80% v/v Der f faecal particles,
• wherein the allergen extract comprises Der f 1, Der f 2, Der p 1, and Der p 2, wherein the concentration (w/v) of the Der f 1, Der f 2, Der p 1, or Der p 2 allergen present in the lowest concentration in the allergen extract is at least 50% of the concentration (w/v) of the Der f 1, Der f 2, Der p 1, or Der p 2 allergen present in the highest concentration, and
• wherein the allergen extract is formulated as a sublingual tablet.