Back to results
US 9,265,816 B2Granted
Immunogenic WT-1 peptides and methods of use thereof
AssigneeSloan-Kettering Institute for Cancer Research
InventorsDavid A. Scheinberg, Rena May
Life of this patent
Estimating the term…
Abstract
This invention provides mutated WT1 peptides SGQAYMFPNAPYLPSCLES (SEQ ID No:41) and QAYMFPNAPYLPSCL (SEQ ID No:42), immunogenic compositions and vaccines comprising same, and methods of treating, reducing the incidence of, and inducing immune responses to a WT1-expressing cancer, comprising same.
Claims12
An isolated, mutated WT1 peptide, comprising:
- a. a binding motif of a human leukocyte antigen (HLA) class II molecule;
- and
- b. a binding motif of an HLA class I molecule, having a point mutation in one or more anchor residues of said binding motif of an HLA class I molecule,
- wherein said isolated, mutated WT1 peptide is SGQAYMFPNAPYLPSCLES (SEQ ID No:
- 41) or QAYMFPNAPYLPSCL (SEQ ID No:
- 42).
3 more elements
An isolated peptide consisting of the amino acid sequence SGQAYMFPNAPYLPSCLES (SEQ ID No:
- 41) or QAYMFPNAPYLPSCL (SEQ ID No:
- 42).
Dependencies are inferred from the claim text.