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US 9,261,509 B2Granted
Methods for monitoring methotrexate therapy
AssigneeThierry Dervieux
InventorThierry Dervieux
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Abstract
The present invention provides methods for assessing efficacy of a methotrexate (MTX) dosing regimen in a patient.
Claims22
A method for assessing efficacy of a methotrexate (MTX) dosing regimen in a patient, comprising
- (a) determining an intracellular amount of
- (i) 5-methyltetrahydrofolate (5CH3THF) polyglutamates (PGs);
- and
- (ii) non-methylated folate PGs
- in a biological sample from the patient before or after initiation of MTX treatment or modification of MTX treatment in the patient;
- and
- (b) assessing efficacy of the MTX dosing regimen in the patient based on the amount of 5CH3THF PGs and the amount of non-methylated folate PGs.
4 more elements
Dependencies are inferred from the claim text.