Use of modified cells for the treatment of multiple sclerosis
AssigneeUniversitäT ZüRich
InventorsRoland Martin, Andreas Lutterotti
Life of this patent
Estimating the term…
Abstract
The present invention describes blood cells chemically coupled with immunodominant myelin peptides and their use in the treatment of Multiple Sclerosis.
Claims19
A chemically coupled cell which is a peripheral blood mononuclear cell (PBMC) or a red blood cell erythrocyte that is chemically coupled to at least six peptides selected from the group consisting of:
- MBP13-32 (SEQ ID NO:1), MBP83-99 (SEQ ID NO:2), MBP111-129 (SEQ ID NO:3), MBP82-98 (SEQ ID NO:8), MBP82-99 (SEQ ID NO:9), MBP82-106 (SEQ ID NO:10), MBP87-106 (SEQ ID NO:11), MBP131-155 (SEQ ID NO:12), MBP146-170 (SEQ ID NO:4), PLP41-58 (SEQ ID NO:13),PLP89-106 (SEQ ID NO:14),PLP95-116 (SEQ ID NO:15), HCLGKWLGHPDKFVGI (SEQ ID NO:5), PLP178-197 (SEQ ID NO:16), SKTSASIGSLCADARMYGVL (SEQ ID NO:17), MOG1-20 (SEQ ID NO:6), MOG11-30 (SEQ ID NO:18), MOG21-40 (SEQ ID NO:19), MOG35-55 (SEQ ID NO:7), and MOG64-86 (SEQ ID NO:20), wherein MBP is myelin basic protein, PLP is proteolipid protein and MOG is myelin oligodendrocyte protein.
A chemically coupled cell which is a peripheral blood mononuclear cell (PBMC) or a red blood cell (RBC) that is chemically coupled to each peptide in a cocktail of peptides selected from the group consisting of cocktails e-h, j-kk, mm, and nn of tables 5.1-5.3.
A chemically coupled cell which is a peripheral blood mononuclear cell (PBMC) or a red blood cell (RBC) that is chemically coupled to each peptide in a cocktail of peptides selected from the group consisting of cocktails e-h, j-kk, mm, and nn of tables 5.1-5.3 with the proviso that at least one of the myelin basic protein (MBP) peptides has been replaced with the full-length MBP protein.
A chemically coupled cell which is a peripheral blood mononuclear cell (PBMC) or a red blood cell (RBC) that is chemically coupled to each peptide in a cocktail of peptides selected from the group consisting of cocktails e-h, j-kk, mm, and nn with the proviso that at least one of the proteolipid protein (PLP) peptides has been replaced with the full-length PLP protein of SEQ ID NO:
- 21.
A chemically coupled cell which is a peripheral blood mononuclear cell (PBMC) or a red blood cell (RBC) that is chemically coupled to each peptide in a cocktail of peptides selected from the group consisting of cocktails e-h, j-kk, mm, and nn with the proviso that at least one of the myelin oligodendrocyte glycoprotein (MOG) peptides has been replaced with the full-length MOG protein according to SEQ ID NO:
- 23.
Dependencies are inferred from the claim text.