Ionic silicone hydrogels having improved hydrolytic stability
AssigneeJohnson & Johnson Vision Care, Inc.
InventorsOsman Rathore, Zohra Fadli, Mark Lada, James D. Ford, Azaam Alli, Yongcheng Li
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Abstract
The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.
Claims21
A polymer formed from reactive components comprising about 0.2 to about 0.8 weight % of at least one anionic component and at least one silicone component selected from the group consisting of reactive polydialkylsiloxane selected from compounds of Formula I:
- wherein b=2 to 20;
- one terminal R1 comprises at least one ethylenically unsaturated moiety, the remaining terminal R1 are independently selected from the group consisting of monovalent alkyl groups having 2 to 16 carbon atoms, and the remaining R1 are selected from the group consisting of monovalent alkyl groups having 1 to 16 carbon atoms, wherein said polymer absorbs at least about 10 μg lysozyme and less than about 5 μg lipocalin.
Dependencies are inferred from the claim text.