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US 9,259,392 B2Granted
Cochleate compositions directed against expression of proteins
AssigneeRutgers, The State University of New Jersey
InventorsSusan Gould-Fogerite, Raphael J. Mannino, Patrick Ahl, Gaofeng Shang, Zi Wei Chen, Sara L. Krause-Elsmore
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Abstract
Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
Claims16
An siRNA-cochleate composition comprising:
- a cochleate;
- and
- an siRNA associated with the cochleate,
- wherein the cochleate comprises a negatively charged lipid component and a multivalent cation component, wherein the siRNA is complexed with a transfection agent prior to contacting a liposome, wherein the transfection agent is a cationic transfection agent.
1 more element
A method of forming an siRNA-cochleate composition comprising:
- complexing an siRNA with a transfection agent;
- contacting the complexed siRNA with a liposome;
- and
- precipitating the liposome and the complexed siRNA to form an siRNA-cochleate composition,
- wherein the cochleate comprises a negatively charged lipid component and a multivalent cation component, wherein the transfection agent is a cationic transfection agent.
2 more elements
Dependencies are inferred from the claim text.