Method to estimate interfractional and intrafractional organ motion for adaptive external beam radiotherapy

A therapy system comprising:

• at least one processor programmed to:
• receive a planning image of a region of a subject, the subject including a target and/or an organ at risk (OAR), and the subject being associated with an optical fiber and the optical fiber acting as a surrogate for the target and/or the OAR;
• determine a reference location and shape in the planning image for one or more of the target and/or the OAR;
• determine a reference location and/or shape from the planning image of the optical fiber;
• wherein one or more of:
• (1) the reference location and/or shape of the optical fiber;
• and (2) the current location and/or shape of the optical fiber, are determined using fiber Bragg gratings of different Bragg wavelengths along the length of the optical fiber, and;
• determine deviations between the reference location and/or shape of the surrogate and a current location and/or shape of the surrogate.

A therapy system comprising:

• a structure configured to carry one or more dosimeters, the dosimeters configured to be implanted in a subject to measure dose delivered to a target and/or an organ at risk (OAR) of the subject;
• shrink wrap configured to be implanted with and secure in the dosimeter directly or indirectly to at least one of the target, the OAR, and tissue proximate to the target and/or OAR;
• and,
• at least one processor programmed to:
• receive dosimetric data indicating dose delivered to the target and/or the OAR from the dosimeters;
• and,
• determine deviations between a planned dose distribution and a delivered dose distribution, the delivered dose distribution determined from the dosimetric data.

A method for therapy planning comprising:

• receiving a planning image of a region of a subject, the subject including a target and/or an organ at risk (OAR), and the subject associated with a surrogate and a dosimeter, the surrogate acting as a surrogate for the target and/or the OAR, and the dosimeter measuring dose delivered to the target and/or the OAR, wherein the surrogate includes an optic fiber structure;
• implanting the optic fiber structure and the dosimeter in the subject proximate to the target and/or the OAR;
• determining a reference location and shape in the planning image for one or more of the target and/or the OAR;
• determining a reference location and/or shape from the planning image of each of the surrogate and/or the dosimeter;
• and
• determining deviations between one or more of:
• the reference location and/or shape of the surrogate and a current location and/or shape of the surrogate;
• and,
• a planned dose distribution and a delivered dose distribution, the delivered dose distribution determined from dosimetric data and the reference location and/or shape of the dosimeter.

A therapy system comprising:

• at least one processor programmed to:
• receive a planning image of a region of a subject, the subject including a target and/or an organ at risk (OAR), and the subject being associated with at least one surrogate and/or a dosimeter, the surrogate acting as a surrogate for the target and/or the OAR, and the dosimeter measuring dose delivered to the target and/or the OAR, wherein the surrogate and/or the dosimeter are configured to be implanted within the subject and secured indirectly to the at least one of the target, the OAR and tissue proximate the target and/or the OAR using a shrink wrap;
• determine a reference location and shape in the planning image for one or more of the target and/or the OAR;
• determine a reference location and/or shape from the planning image of each of the surrogate and/or the dosimeter;
• determine deviations between one or more of:
• the reference location and/or shape of the surrogate and a current location and/or shape of the surrogate;
• and,
• a planned dose distribution and a delivered dose distribution, the delivered dose distribution determined from dosimetric data and the reference location and/or shape of the dosimeter.