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US 9,255,134 B2Granted
Lytic domain fusion constructs and methods of making and using same
AssigneesEsperance Pharmaceuticals, Inc., Board of Supervisors of Louisana State University and Agricultural and Mechanical College
InventorsCarola Leuschner, Hector Alila
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Abstract
The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
Claims35
A fusion construct comprising a first lytic domain and a second domain, wherein said first lytic domain consists of peptide KFAKFAKKFAKFAKK (SEQ. ID NO. 1) or peptide KFAKFAKKFAKFAKKFAK (SEQ. ID NO. 4);
- and said second domain comprises a luteinizing hormone releasing hormone (LHRH), an LHRH fragment, or an LHRH analog.
Dependencies are inferred from the claim text.