Alteration of cell membrane for new functions using IL-2 and streptavidin
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorHaval Shirwan
Life of this patent
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Abstract
Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous DNA. DNA sequences, the proteins and polypeptides embodying these sequences are disclosed for modulating the immune system. The modulations include down-regulation, up-regulation and apoptosis.
Claims10
A chimeric protein comprising IL-2 (Interleukin-2), wherein the chimeric protein is encoded by a nucleic acid comprising SEQ ID NO:4.
An isolated nucleic acid having a nucleotide sequence comprising SEQ ID NO:4.
Dependencies are inferred from the claim text.