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US 9,249,234 B2Granted
Light-sensitive ion-passing molecules
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKarl Deisseroth, Feng Zhang, Viviana Gradinaru
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Abstract
The invention provides polynucleotides and methods for expressing light-activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The invention also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
Claims13
A light-activated protein comprising, in order from amino terminus (N-terminus) to carboxyl terminus (C-terminus):
- a) a core amino acid sequence at least 95% identical to the sequence shown in SEQ ID NO:3, SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:4;
- b) an endoplasmic reticulum (ER) export signal;
- and
- c) a membrane trafficking signal.
1 more element
Dependencies are inferred from the claim text.