Reovirus vaccines and methods of use therefor
AssigneeVanderbilt University
InventorsTerence S. Dermody, Karl W. Boehme, Mine Ikizler, Gregory J. Wilson, James D. Chappell
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Abstract
The present invention provides for modified reoviruses that carry α-helical epitopes from a variety of pathogens, as well as methods of using such modified reoviruses to generate immune responses against those epitopes in hosts.
Claims21
A modified reovirus σ1 protein comprising a first α-helical antigenic epitope from a non-reovirus antigen inserted into an α-helical region of said protein.
A reovirus vector encoding a reovirus σ1 protein comprising a first α-helical antigenic epitope from a non-reovirus antigen inserted into an α-helical region of said protein.
A reovirus particle comprising a vector encoding a reovirus σ1 protein comprising a first α-helical antigenic epitope from a non-reovirus antigen inserted into α-helical region of said protein.
A method of inducing an immune response in a subject comprising administering to said subject a modified reovirus σ1 protein comprising a first α-helical antigenic epitope from a non-reovirus antigen inserted into an α-helical region of said protein, a reovirus vector encoding said modified reovirus σ1 protein, or a viral particle comprising a vector encoding said modified reovirus σ1 protein.
A method of expressing an epitope in a subject comprising administering to said subject a modified reovirus σ1 protein comprising a first α-helical antigenic epitope from an antigen inserted into an α-helical region of said protein.
Dependencies are inferred from the claim text.