Aniline derivatives, their preparation and their therapeutic application
AssigneeFovea Pharmaceuticals
InventorsJohn Feutrill, Caroline Leriche, David Middlemiss
Life of this patent
Estimating the term…
Abstract
The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.
Claims28
A compound of formula (I) or formula (II), wherein the compound of formula (II) is a prodrug of the compound of formula (I):
- wherein
- R1a represents H, a halogen, a (C1-C6)alkyl or a CN;
- R1b represents H, a halogen or a (C1-C6)alkyl;
- R1c represents H or a (C1-C6)alkyl;
- R2 represents H, a halogen, an OH, an O—(C1-C6)alkyl or a (C1-C6)alkyl;
- R3 represents H, a halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or a CN;
- R4 represents H, a halogen or a (C1-C6)alkyl;
- R5 represents H or F;
- R6 represents an O—(C1-C6)alkyl, an O—(C1-C6)alkyl-heterocycloalkyl, an NH2, an NH—(C1-C6)alkyl, an O—(C1-C6)alkyl optionally substituted by one to three hydroxyl groups, or an O—(C1-C6)alkyl—O—CO(C1-C6)alkyl);
- R7 represents H or F;
- R8 represents H or F;
- and
- R9 represents H or a (C1-C6)alkyl,
- or an enantiomer thereof.
Dependencies are inferred from the claim text.