Medical devices having bioerodable layers for the release of therapeutic agents
AssigneeBoston Scientific Scimed, Inc.
InventorsJeffrey S. Lindquist, Peter G. Edelman
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Abstract
According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate and (b) bioerodable polymeric layer over the substrate that contains (i) one or more biodegradable polymers, (ii) one or more therapeutic agents, and (iii) one or more plasticizers.
Claims20
A medical device comprising (a) a substrate and (b) a bioerodable polymeric layer over the substrate that comprises (i) 50 wt % to 99 wt % of a biodegradable polymer selected from poly(lactic acid) and poly(lactic acid-co-glycolic acid), said biodegradable polymer having a number average molecular weight of 10,000 or more, (ii) a therapeutic agent, and (iii) 1 wt % to 50 wt % of a plasticizer selected from glycolic acid, an oligomer comprising glycolic acid, and combinations thereof.
A medical device comprising (a) a substrate;
- and (b) a bioerodable polymeric layer over the substrate that comprises (i) 50 wt % to 99 wt % of a biodegradable polymer comprising a first monomer, said biodegradable polymer having a number average molecular weight of 10,000 or more, (ii) a therapeutic agent and (iii) 1 wt % to 50 wt % of a plasticizer selected from free first monomer, an oligomer comprising said first monomer, a short polymer comprising said first monomer, a plasticizing polymer that is miscible with said biodegradable polymer, and combinations thereof, wherein the bioerodable polymeric layer has a plasticizer-rich surface, wherein the plasticizer-rich surface is formed by application of a composition containing said plasticizer and said therapeutic agent to the surface of a bioerodable polymeric layer that contains said biodegradable polymer, said plasticizer and said therapeutic agent.
A medical device comprising (a) a substrate;
- and (b) a first bioerodible polymeric layer over the substrate that comprises (i) 50 wt % to 99 wt % of poly(lactic acid-co-glycolic acid) as a first biodegradable polymer having a number average molecular weight of 10,000 or more, and (ii) a first therapeutic agent;
- and (c) a second bioerodible polymeric layer over the first bioerodible polymeric layer that comprises (i) 50 wt % to 99 wt % of poly(lactic-co-glycolic acid) as a second biodearadable polymer, which second biodearadable polymer may be the same as or different from the first biodegradable polymer, said second biodegradable polymer having a number average molecular weight of 10,000 or ore (ii) a second therapeutic agent, which may be the same as or different from the first therapeutic agent, and (iii) 1 wt % to 50 wt % of a plasticizer selected from glycolic acid, an oligomer comprising lactic acid, or an oligomer comprising glycolic acid, wherein said first bioerodible polymeric layer does not contain said plasticizer.
Dependencies are inferred from the claim text.