Catheter locking solution having antimicrobial and anticoagulation properties
AssigneeBecton, Dickinson and Company
InventorsJohn J. Kelley, III, Thelma I. Valdes
Life of this patent
Estimating the term…
Abstract
The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.
Claims29
A catheter locking solution comprising:
- a local anesthetic selected from the group consisting of dibucaine, tetracaine, and a combination thereof, in an amount effective to reduce microbial growth and coagulation in an implanted catheter;
- and
- a viscosifying agent, the catheter locking solution having a viscosity of less than or equal to 4 mPa·s.
A pre-filled syringe comprising a syringe containing a locking solution, said locking solution comprising:
- a local anesthetic selected from the group consisting of dibucaine, tetracaine, and a combination thereof, in an amount effective to reduce microbial growth and coagulation in an implanted catheter;
- and
- a viscosifying agent,
- the catheter locking solution having a viscosity of less than or equal to 4 mPa·s.
A catheter comprising a tube defining a lumen therethrough, wherein at least a portion of the lumen is infused with a catheter locking solution, said catheter locking solution comprising:
- a local anesthetic selected from the group consisting of dibucaine, tetracaine, and a combination thereof, in an amount effective to reduce microbial growth and coagulation in an implanted catheter;
- and
- a viscosifying agent,
- the catheter locking solution having a viscosity of less than or equal to 4 mPa·s.
A catheter locking solution comprising:
- a local anesthetic having anticoagulant and antimicrobial activity, wherein the local anesthetic is tetracaine;
- and
- a viscosifying agent, wherein the viscosifying agent is polyethylene glycol,
- wherein the local anesthetic is present in an amount of 0.24 mg/mL-28.2 mg/mL, and
- the catheter locking solution having a viscosity of less than or equal to 4 mPa·s.
A catheter locking solution comprising:
- a local anesthetic having anticoagulant and antimicrobial activity, wherein the local anesthetic is dibucaine;
- and
- a viscosifying agent, wherein the viscosifying agents is polyethylene glycol, wherein the local anesthetic is present in an amount of 0.24 mg/mL-28.2 mg/mL,
- the catheter locking solution having a viscosity of less than or equal to 4 mPa·s.
A method of reducing microbial activity and coagulation in a catheter, the method comprising:
- providing a catheter having an interior surface and an exterior surface;
- and
- infusing, into at least a portion of the interior surface, a catheter locking solution comprising a local anesthetic selected from the group consisting of dibucaine, tetracaine, and a combination thereof, in an amount effective to reduce microbial growth and coagulation in an implanted catheter and a viscosifying agent.
Dependencies are inferred from the claim text.