Primate model from the family cercopithecidae infected by a HBV strain of human genotype
AssigneesInstitut National de la Sante et de la Recherche Medicale, Hospices Civils De Lyon, Universite Claude Bernard Lyon 1
InventorsIsabelle Chemin, Christian Trepo
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Abstract
The invention relates to a non-human primate animal model for HBV infection, said animal model being of the Cercopithecidae family.
Claims7
A primate animal model of HBV infection, wherein the primate animal model is a primate of the Cercopithecidae family artificially infected with
- a human hepatitis B virus (HBV) genotype D strain, said human HBV genotype D strain comprising a nucleic acid of sequence SEQ ID NO:1.
A method for providing a primate animal model of HBV infection having a viral load of at least 102 HBV genomic copies/ml, comprising the steps of:
- obtaining an animal of the Cercopithecidae family;
- infecting said animal with an isolated human HBV genotype D strain, said human HBV genotype D strain comprising a nucleic acid of sequence SEQ ID NO:1,
- assaying the viral load of the infected animal, and
- selecting an infected animal having the viral load of at least 102 HBV genomic copies/ml.
A method of infecting a primate animal of the Cercopithecidae family comprising administering to said primate animal
- an isolated human HBV genotype D strain, said human HBV genotype D strain comprising a nucleic acid of sequence SEQ ID NO:1.
Dependencies are inferred from the claim text.