Hydrophilic polymeric particles and methods for making and using same
AssigneeLife Technologies Corporation
InventorsGeir Fonnum, Grete Modahl, Nini Kjus, Astrid Evenroed Molteberg, Diem Tran, Jo Aaserud, M. Talha Gokmen, Steven Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
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Abstract
A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
Claims19
A method of forming a particle, the method comprising:
- promoting a seed particle in an aqueous suspension to form a disperse phase within the aqueous suspension, wherein promoting the seed particle includes mixing a solvent and a promoting agent with the seed particle;
- adding a hydrophilic monomer having a hydrophobic protection group to the disperse phase;
- in the disperse phase, polymerizing a plurality of mer units of the hydrophilic monomer, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups;
- and
- converting the polymeric particle to a hydrogel particle.
A method of forming a particle, the method comprising:
- promoting a seed particle in an aqueous suspension to form a disperse phase within the aqueous suspension, wherein promoting the seed particle includes mixing a solvent and a promoting agent with the seed particle;
- adding an acrylamide monomer having a hydrophobic protection group to the disperse phase;
- in the disperse phase, polymerizing a plurality of mer units of the acrylamide monomer, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups;
- and
- converting the polymeric particle to a hydrophilic particle.
A method of forming a particle, the method comprising:
- promoting a seed particle in an aqueous suspension to form a disperse phase within the aqueous suspension, wherein promoting the seed particle includes mixing a solvent and a promoting agent with the seed particle;
- adding a radically polymerizable monomer and the dyacrylamide crosslinker having a hydrophobic protection group;
- in the disperse phase, polymerizing a plurality of mer units of the radically polymerizable monomer with the diacrylamide crosslinker, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups;
- and
- removing at least a portion of plurality of the hydrophobic protection groups.
Dependencies are inferred from the claim text.