Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity
AssigneeThe Trustees of Boston College
InventorsJianmin Gao, Fang Wang
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Abstract
Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.
Claims31
An anti-microbial composition comprising at least one Gramicidin A peptide analog or derivative having reduced cytotoxicity and increased solubility relative to wild-type Gramicidin A wherein the wild-type Gramicidin A comprises the amino acid sequence of SEQ ID NO:
- 2, and wherein the at least one Gramicidin A peptide analog or derivative comprises the amino acid sequence of SEQ ID NO:
- 2, wherein one of the d-Leucine amino acids at positions 10 or 14 of the SEQ ID NO:
- 2 have been replaced or substituted with a cationic residue.
An anti-microbial composition comprising at least one Gramicidin A peptide analog or derivative having reduced cytotoxicity and increased solubility relative to wild-type Gramicidin A wherein the wild-type Gramicidin A comprises the amino acid sequence of SEQ ID NO:
- 2, and wherein the at least one Gramicidin A peptide analog or derivative comprises the amino acid sequence of SEQ ID NO:
- 2, wherein two or more of the d-Leucine amino acids at positions 10, 12, or 14 of the SEQ ID NO:
- 2 have been replaced or substituted with a cationic residue.
Dependencies are inferred from the claim text.