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US 9,243,031 B2Granted
Complex-forming compounds
AssigneeStratoxer(S) Kft.
InventorsG. Imre Csizmadia, Zoltan Mucsi, Andrea Narcisz Koczkas
Life of this patent
Estimating the term…
Abstract
Present invention refers to complex-forming compounds of the general formula and the use and preparation thereof.
Claims30
A compound of formula (I)
- wherein R1 and R2 are identical or different groups of the following formula (II)
- or a salt or metal ion complex thereof,
- wherein
- n stands for 0, 1 or 2,
- Q stands for a carboxyl group,
- X stands for an oxygen, sulfur or nitrogen atom,
- in which the substituent of the nitrogen is a hydrogen atom or a straight or branched C1-6 carbon chain alkyl group;
- R3, R4 and R5 are identical groups or different from each other and stand for a hydrogen atom, halogen atom, or a straight or branched C1-6 carbon chain alkyl group,
- C1-6 alkylene group, C1-6 alkynyl group, aryl, aralkyl or heteroaryl group, saturated or unsaturated cycloalkyl group or a substituted or unsubstituted heterocyclic group containing one or more sulfur, oxygen or nitrogen atoms, which are optionally substituted with one or more identical or different substituents;
- or R5 and one valency of the adjacent carbon atom of R6 form a double bond together according to formula (II-A)
- where n in formula (II-A) is 1 or 2;
- R6 stands for a saturated or unsaturated C1-C2 alkyl group, which is optionally substituted with one or more identical or different halogen atoms or straight or branched C1-6 alkyl group, C1-6 alkylene group, C1-6 alkynyl group or aryl group, aralkyl group, heteroaryl group, or a saturated or unsaturated heterocyclic group containing one or more sulfur, oxygen or nitrogen atoms, which substituents optionally contain one or more identical or different further substituents, or R6 is a group of the following formula
- wherein the two carbon atoms form with the group R7 a substituted or unsubstituted 3-7 membered, saturated or unsaturated ring,
- or R5 and R6 form a substituted or unsubstituted 3-7 membered ring.
11 more elements
A compound, which is one of the following compounds
- 2-(2-{16-[(Dicarboxymethyl-carbamoyl)-methyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-acetylamino)-malonic acid of formula (P-1):
- 2-(2-{16-[(1,2-Dicarboxy-ethylcarbamoyl)-methyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-acetylamino)-succinic acid of formula (P-2):
- 2-(2-{16-[(1,3-Dicarboxy-propylcarbamoyl)-methyl]-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadec-7-yl}-acetylamino)-glutaric acid of formula (P-3):
- or a salt or metal ion complex thereof.
1 more element
The compound of formula (VII)
- wherein
- n stands for 0, 1 or 2,
- X stands for an oxygen, sulfur or nitrogen atom,
- in which the substituent of the nitrogen is a hydrogen atom or a straight or branched C1-6 carbon chain alkyl group;
- R3, R4 and R5 are identical groups or different from each other and stand for a hydrogen atom, halogen atom, or a straight or branched C1-6 carbon chain alkyl group,
- C1-6 alkylene group, C1-6 alkynyl group, aryl, aralkyl or heteroaryl group, saturated or unsaturated cycloalkyl group or a substituted or unsubstituted heterocyclic group containing one or more sulfur, oxygen or nitrogen atoms, which are optionally substituted with one or more identical or different substituents;
- or R5 and one valency of the adjacent carbon atom of R6 form a double bond together according to formula (II-A)
- where n in formula (II-A) is 1 or 2;
- R6 stands for a saturated or unsaturated C1-C2 alkyl group, which is optionally substituted with one or more identical or different halogen atoms or straight or branched C1-6 alkyl group, C1-6 alkylene group, C1-6 alkynyl group or aryl group, aralkyl group, heteroaryl group, or a saturated or unsaturated heterocyclic group containing one or more sulfur, oxygen or nitrogen atoms, which substituents optionally contain one or more identical or different further substituents, or R6 is a group of the following formula
- wherein the two carbon atoms form with the group R7 a substituted or unsubstituted 3-7 membered, saturated or unsaturated ring, and
- Q′,Q″, P′ and P″ are identical or different protected carboxyl groups or a salt or metal ion complex thereof.
8 more elements
Dependencies are inferred from the claim text.