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US 9,242,028 B2Granted
Microgel particle
AssigneeGelexir Healthcare Limited
InventorsBrian Saunders, Anthony John Freemont, Jennifer Saunders
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions comprising a pH-responsive microgel particle, wherein the particle is adapted to undergo a conformational change in response to a variation in pH. The compositions may be used as medicaments for treating a disease characterized by damaged or degenerated soft tissues (e.g. intervertebral discs).
Claims31
A method of introducing a composition into a subject in need thereof comprising:
- (i) providing a composition comprising a dispersion comprising pH-responsive microgel particles, wherein the microgel particles have a diameter between 1 nm to 10 μm prior to introduction into the subject and the microgel particles comprise a polymer of pH-responsive co-monomer units and functional cross-linked co-monomer units;
- and
- (ii) injecting an effective amount of the composition into a tissue selected from the group consisting of a vertebral disc, an invertebral disc, a nucleus pulposus, clefts of a nucleus pulposus of an intervertebral disc, an articular joint, a hip joint, an elbow joint, an ankle joint, a knee joint, a wrist joint, and cartilage, so as to introduce the composition into the subject.
Dependencies are inferred from the claim text.