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US 9,238,038 B2Granted
Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
AssigneesThe University of North Carolina at Chapel Hill, Novan, Inc.
InventorsMark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
Life of this patent
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Abstract
Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
Claims18
A nitric oxide-releasing macromolecule comprising
- at least two different NO donor structures of the same class,
- wherein the at least two different NO donor structures have the same mechanism for release of NO and are different in chemical structure, and
- wherein the at least two different NO donor structures are diazeniumdiolate donor structures and have different nitric oxide release kinetics.
Dependencies are inferred from the claim text.