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AssigneesAlbert Einstein College of Medicine, President and Fellows of Harvard College, Whitehead Institute for Biomedical Research
InventorsKartik Chandran, Sean Whelan, Thijn Brummelkamp, Jan Carette, Matthijs Raaben
Estimating the term…
Methods and assays for treating a subject with a filovirus infection using an agent that inhibits Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4. Methods for screening for an agent that treats and/or prevents infection of a subject with a filovirus, where the methods comprise determining whether the agent inhibits one or more of Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41. BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4, wherein an agent that inhibits one or more of NPCI, VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is a candidate for treating and/or preventing an infection with a filovirus and wherein an agent that does not inhibit NPCI, VPSII, VPSI6, VPSI8, VPS33A. VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is not a candidate for treating and/or preventing an infection with a filovirus.
A method for treating a subject infected with an ebolavirus or a marburgvirus or for preventing an infection with an ebolavirus or a marburgvirus in a subject exposed to an ebolavirus or a marburgvirus comprising administering to the subject an agent that inhibits Niemann-Pick C1 (NPC1) in an amount effective to treat and/or prevent infection with an ebolavirus or a marburgvirus.
Dependencies are inferred from the claim text.