Recombinant attenuated parvovirus
AssigneeIntervet Inc.
InventorNorman Spibey
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Abstract
The invention is in the field of virus vaccines for protecting animals against infection by parvovirus, their production and use. More in particular, the invention is related to a vaccine comprising an attenuated parvovirus comprising a capsid protein or fragment thereof derivable from another parvovirus. Surprisingly it was found that such a vaccine was capable of inducing higher titers of protecting antibodies against a challenge with the second type of parvovirus strains while maintaining good immunity against the first type of parvovirus. Recombinant virus strains also remained attenuated.
Claims16
An attenuated recombinant parvovirus comprising a DNA sequence obtained from an attenuated first parvovirus;
- wherein the DNA sequence encoding the capsid protein or fragment thereof of said first parvovirus is replaced by a DNA sequence encoding a capsid protein or fragment thereof derived from a second parvovirus;
- wherein said first parvovirus is a type 2 canine parvovirus;
- wherein said second parvovirus is a type 2c canine parvovirus;
- wherein the attenuated recombinant canine parvovirus comprises the DNA sequence encoding the capsid protein of a canine parvovirus type 2c isolate within the DNA sequence of an attenuated canine parvovirus type 2 virus;
- and wherein said fragment thereof of said second parvovirus comprises at least one amino acid difference from said fragment thereof of said first parvovirus.
Dependencies are inferred from the claim text.