Creating bioengineered lymph nodes
AssigneeH. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorJames J. Mule
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Abstract
The invention provides compositions and methods of treating various conditions, including tumors, with compositions comprising dendritic cells expressing exogenous chemokines.
Claims26
A composition comprising an isolated, engineered dendritic cell comprising exogenous cDNAs encoding exogenous Chemokine (C—C Motif) Ligand (CCL) 8 (CCL-8), CCL-18, and C—X—C Motif Chemokine 13 (CXCL-13).
An isolated, engineered dendritic cell comprising exogenous cDNAs encoding exogenous CCL-8, CCL-18, and CXCL-13.
A composition comprising an isolated, engineered dendritic cell transduced with plasmids, cosmids, or viral vectors encoding exogenous CCL-8, CCL-18, and CXCL-13.
An isolated engineered dendritic cell transduced with plasmids, cosmids, or viral vectors encoding exogenous CCL-8, CCL-18, and CXCL-13.
Dependencies are inferred from the claim text.