Modified Cpn10 and PRR signalling
AssigneeCBio Limited
InventorsDean Jason Naylor, Richard James Brown, Christopher Bruce Howard, Christopher John De Bakker, Linda Alisson Ward, Jeanette Elizabeth Stok, Andrew Leigh James, Daniel Scott Lambert, Kylie Jane Ralston, Walter Rene Antonius Van Heumen
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Abstract
The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
Claims7
An isolated Cpn10 polypeptide possessing an increased affinity for a PRR ligand compared to Ala-Cpn10 polypeptide, the isolated Cpn10 polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NO:58, SEQ ID NO:88, SEQ ID NO:91, SEQ ID NO:94, SEQ ID NO:181, SEQ ID NO:193, SEQ ID NO:229, SEQ ID NO:256, SEQ ID NO:259, SEQ ID NO:304, SEQ ID NO:310, SEQ ID NO:328 and SEQ ID NO:349.
Dependencies are inferred from the claim text.