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US 9,233,925 B2Granted
Process for preparation of roflumilast
AssigneeScinopharm (Changshu) Pharmaceuticals, Ltd.
InventorsYi-Jing Chen, Stanislaw Pikul, Shen-Chun Kuo, Guo-dong Chu
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Abstract
The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
Claims3
A compound of formula Vc:
- wherein
- Rl and R2 are independently selected from the group consisting of H;
- C1-6 alkyl;
- C3-7 cycloalkyl;
- C3-7 cycloalkylmethyl;
- and C1-4 alkyl which is partially or completely substituted with fluorine.
3 more elements
Dependencies are inferred from the claim text.