Cu-mediated annulation for the production of 1-amino-2-naphthalenecarboxylic acid derivatives

A one pot process for the preparation of compound of formula (A) comprising reacting compound of formula (B) with CuCN in DMF at a temperature in the range of 145° -155° C. for period in the range of 10 to 12 hours;

• Wherein, R1, R2, R3, R4 are selected independently from the group consisting of hydrogen, alkyl, alkoxy, halo, NO2 or CN;
• R5 is selected independently from the group consisting of H, CH3, C2H5, Ph or CH3C6H4;
• R6 is selected independently from the group consisting of CO2Et, CO2Me, CO2Ph, COMe, COPh, CN, SO2Ph, CONH2 or NO2;
• R7 is selected independently from the group consisting of H, CH3 or Ph;
• and
• X represents halo group.