Back to results
US 9,227,021 B2Granted
Microneedle roller (MNR) infusion system
AssigneeGenesis Biosystems, Inc.
InventorBrian Buss
Life of this patent
Estimating the term…
Abstract
A micro-needle roller (MNR) infusion system for transdermal delivery of active agents, skin-care products, and other topical formulations is described herein. The infusion system of the instant invention comprises a needle roller assembly with 0.25 mm needles enclosed in a housing with a vacuum line and a disposable cartridge having the active agent, the skin-care product or the topical formulation. The vacuum delivers the fluid and ensures that the skin is being pulled against the needle wheel surface to ensure that penetration of the needles is complete into the skin, simultaneously the fluid is flowing to the wheel and to skin as it rolls along with the outer housing of the tip cap assembly being occluded to the skin surface.
Claims34
A device for a transdermal delivery of one or more active agents, skin-care products, topical formulations or combinations thereof to a subject comprising:
- a housing comprising a cavity, wherein the cavity is adapted to receive one or more gas lines, vacuum lines or both, one or more removable reservoirs, cartridges or compartments, and one or more active agents, skin-care products, topical formulations or combinations thereof are contained in the cavity or in the removable reservoirs, cartridges or compartments;
- and
- a tip cap assembly removably attached to the housing assembly, wherein the tip cap assembly encloses a skin penetrating device in fluid connection with the cavity in the housing, wherein the skin penetrating device comprises a micro-needle roller comprising one or more solid micro-needles attached to and supported by a roller surface, wherein a movement of the roller over the skin of the subject causes a rotation of the roller and brings the solid micro-needles into contact with the skin of the subject through an opening in the tip cap assembly resulting in a penetration of the skin and the transdermal delivery of the one or more active agents, the skin-care products, the topical formulations or combinations thereof present on the roller, wherein the one or more active agents the skin-care products, the topical formulations or combinations thereof is drawn from the cavity, one or more removable reservoirs, cartridges or compartments by a vacuum pulled through the vacuum line.
A method for transdermal delivery of one or more one or more active agents, skin-care products, topical formulations or combinations thereof to a subject comprising the steps of:
- identifying a subject in need of the transdermal delivery;
- providing a transdermal delivery device comprising:
- a housing assembly comprising a cavity, wherein the cavity encloses a vacuum line, a vacuum chamber or any vacuum generating device, and one or more removable reservoirs, cartridges or compartments, wherein the one or more active agents, the skin-care products, the topical formulations, or combinations thereof is contained in the one or more removable reservoirs, cartridges or compartments;
- and
- a tip cap assembly removably attached to the housing assembly, wherein the tip cap assembly encloses a skin penetrating device in fluid connection with the cavity in the housing, wherein the skin penetrating device comprises a micro-needle roller comprising one or more solid micro-needles attached to and supported by a roller surface;
- depressing a switch or a button on the housing assembly to power-on the device and turn on a vacuum to draw the one or more active agents, skin-care products, topical formulations or combinations thereof from the one or more removable reservoirs, cartridges or compartments by the vacuum pulled through the vacuum line;
- moving the roller over the skin of the subject repeatedly thereby causing a rotation of the roller;
- and
- contacting the solid micro-needles with the skin of the subject through an opening in the tip cap assembly resulting in a penetration of the skin and the transdermal delivery of the one or more active agents, the skin-care products, the topical formulations or combinations thereof present on the roller through an opening in the tip cap assembly.
6 more elements
A method of treating a skin condition in a subject by a delivery of one or more one or more active agents, skin-care products, topical formulations or combinations thereof to a subject comprising the steps of:
- identifying a subject in need of treatment against the skin condition;
- providing a transdermal delivery device comprising:
- a housing assembly comprising a cavity, wherein the cavity encloses a vacuum line, a vacuum chamber or any vacuum generating device, and one or more of removable reservoirs, cartridges or compartments, wherein the one or more active agent, the skin-care products, the topical formulations or combinations thereof is contained in the one or more removable reservoirs, cartridges or compartments;
- and
- a tip cap assembly removably attached to the housing assembly, wherein the tip cap assembly encloses a skin penetrating device in fluid connection with the cavity in the housing, wherein the skin penetrating device comprises a micro-needle roller comprising one or more solid micro-needles attached to and supported by a roller surface,
- depressing a switch or a button on the housing assembly to power-on the device and turn on a vacuum to draw the active agent, skin-care products, topical formulations or combinations thereof from the one or more removable reservoirs, cartridges or compartments by the vacuum pulled through the vacuum line;
- moving the roller over the skin of the subject repeatedly thereby causing a rotation of the roller;
- and
- contacting the solid micro-needles with the skin of the subject through an opening in the tip cap assembly resulting in a penetration of the skin and the transdermal delivery of the one or more active agents, the skin-care products, the topical formulations or combinations thereof present on the roller through an opening in the tip cap assembly.
6 more elements
A device for a transdermal delivery of one or more active agents, skin-care products, topical formulations or combinations thereof to a subject comprising:
- a housing assembly comprising a cavity, wherein the cavity encloses a vacuum line, a vacuum chamber or any vacuum generating device, and one or more of removable reservoirs, cartridges or compartments, wherein the one or more active agents, the skin-care products, the topical formulations or combinations thereof is contained in the one or more removable reservoirs, cartridges or compartments;
- and
- a tip cap assembly removably attached to the housing assembly, wherein the tip cap assembly encloses a skin penetrating device in fluid connection with the cavity in the housing, wherein the skin penetrating device comprises a micro-needle roller, wherein one or more solid micro-needles attached to and supported by a roller surface, wherein a movement of the roller over the skin of the subject causes a rotation of the roller and brings the solid micro-needles into contact with the skin through an opening in the tip cap assembly resulting in a penetration of the skin and the transdermal delivery of the one or more active agents, the skin-care products, the topical formulations or combinations thereof along the solid micro-needles.
A device for a transdermal delivery of one or more active agents, skin-care products, topical formulations or combinations thereof to a subject comprising:
- a housing assembly comprising a cavity, wherein the cavity encloses a vacuum line, a vacuum chamber or any vacuum generating device, and one or more of removable reservoirs, cartridges or compartments, wherein the one or more active agents, the skin-care products, topical formulations or combinations thereof is contained in the one or more removable reservoirs, cartridges or compartments;
- and
- a tip cap assembly removably attached to the housing assembly, wherein the tip cap assembly encloses a skin penetrating device in fluid connection with the cavity in the housing, wherein the skin penetrating device comprises a micro-needle roller, wherein one or more solid micro-needles are attached to and supported by a roller surface, wherein a movement of the roller over the skin of the subject causes a rotation of the roller and brings the solid micro-needles into contact with the skin through an opening in the tip cap assembly resulting in a penetration of the skin and the transdermal delivery of the one or more active agents, the skin-care products, the topical formulations or combinations thereof along the solid micro-needles, wherein the one or more active agents, the skin-care products, the topical formulations or combinations thereof is drawn from the one or more removable reservoirs, cartridges or compartments by a vacuum pulled through the vacuum line.
Dependencies are inferred from the claim text.