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US 9,226,992 B2Granted
Implantable cartilaginous tissue repair device
AssigneeOrthox Limited
InventorsStephen Mann, David Philip Knight, Nicholas James Vavasour Skaer, Caroline Bertram, Richard O. C. Oreffo, Helmtrud I. Roach, Andrew Michael Collins
Life of this patent
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Abstract
A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fiber lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fiber lay; with or without an integral means of firmly anchoring the device to a patient's bone.
Claims20
An implantable cartilaginous tissue repair device comprising:
- a biocompatible and at least partially bioresorbable three-dimensional fibre lay comprising silk fibres
- at least partially infiltrated by
- a biocompatible and at least partially bioresorbable, substantially porous hydrogel comprising silk protein cross-linked by hydrogen bonds to form a beta sheet configuration, the hydrogel being cross-linked to the fibre lay,
- wherein the hydrogel is non-flowable and has an open pore structure,
- whereby, in use, cells can be introduced into and contained within at least some pores of the open pore structure of the hydrogel.
2 more elements
An implantable tissue repair device comprising:
- a biocompatible and at least partially bioresorbable fibre lay comprising silk fibres at least partially infiltrated by:
- a biocompatible and at least partially bioresorbable porous hydrogel comprising silk protein cross-linked by hydrogen bonds to form a beta sheet configuration, the hydrogel being cross-linked to the fibre lay, wherein the hydrogel is non-flowable and has an open pore structure, whereby in use cells can be introduced into and contained within at least some pores of the open pore structure of the hydrogel, and
- an integral attachment means for attaching said fibre lay and said porous hydrogel to bone comprising at least one mineralised surface.
Dependencies are inferred from the claim text.