US 9,226,984 B2 · Entrapment of radionuclides in nanoparticle compositions

Abstract

The present invention is directed to the technical field of imaging compositions useful for diagnosing cancer and other diseases in a subject. In particular, the invention relates to a class of diagnostic compounds comprising a novel liposome composition with encapsulated metal entities such as radionuclides, for example 61Cu and 64Cu copper isotopes. The invention further relates to a novel method for loading delivery systems, such as liposome compositions, with metal entities such as radionuclides, and the use of liposomes for targeted diagnosis and treatment of a target site, such as cancerous tissue and, in general, pathological conditions associated with leaky blood vessels. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

Claims16

Dependent claims

A method for preparation of a liposome loaded with metal cations, said method comprising:

a) forming a liposome comprising a vesicle forming component and a water soluble and non-lipophilic chelator enclosed in said liposome;
and
b) entrapping the metal cations within the interior of the liposome by enabling transfer of metal cations across a membrane formed by the vesicle forming component by incubation of the liposome in a solution comprising the metal cations without using an ionophore as transporting molecule.

Dependencies are inferred from the claim text.

Facts

Application

13/992,080Filed 14 Dec 2011 · us provisional application

Priority

DK 2010 7054214 Dec 2010

Published

US 2013/0251630 A126 Sep 2013

Granted

5 Jan 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 51/1237
Liposomes: polymersomes, i.e. liposomes with polymerisable or polymerized bilayer-forming substances
A61K 51/0482
Complexes or complex-forming compounds, i.e. wherein a radioactive metal is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group:…
A61K 51/1203
Characterised by a special physical form, e.g. emulsion, microcapsules, liposomes , characterized by a special physical form, e.g. emulsions,…: in…
A61K 51/1234
Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols: liposomes

Entrapment of radionuclides in nanoparticle compositions

Life of this patent

Entrapment of radionuclides in nanoparticle compositions

Life of this patent

Abstract

Claims16