TNF-α binding proteins
AssigneeAbbVie Inc.
InventorsLorenzo Benatuil, Tariq Ghayur, Carrie L. Goodreau, Peter C. Isakson, Jochen Salfeld
Life of this patent
Estimating the term…
Abstract
Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Claims33
A humanized binding protein or antigen binding fragment thereof comprising an antigen binding domain capable of binding human tumor necrosis factor-alpha (TNF-α), the antigen binding domain comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH region comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 29, 30, 31, 32, and 33, and the VL region comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 34, 35, and 36.
Dependencies are inferred from the claim text.