Anti-sAPPβ antibody
AssigneeShionogi & Co., Ltd.
InventorsTatsuya Takahashi, Junji Onoda, Yasunobu Yoshida, Shoji Yamane, Kouhei Nishitomi, Hidekuni Yamakawa, Akira Yamauchi, Atsushi Morita, Isao Fukuda
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Abstract
Provided are a monoclonal antibody capable of specifically recognizing a specific region of sAPP β or a fragment of said antibody and an assay method and an assay kit using the same, in order to accurately assay sAPPβ contained in a biological sample.
Claims11
A monoclonal antibody raised against soluble amyloid precursor protein β (sAPP β) or an antigen binding fragment thereof which specifically binds to the amino acid sequence of SEQ ID NO:
- 37 within sAPP β, wherein the monoclonal antibody comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 14 and a light chain variable region having the amino acid sequence of SEQ ID NO:
- 15.
A monoclonal antibody against sAPP β or an antigen binding fragment thereof comprising:
- a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 14 and a light chain variable region having the amino acid sequence of SEQ ID NO:
- 15.
A monoclonal antibody against sAPP β or an antigen binding fragment thereof comprising:
- a heavy chain variable region comprising a complementarity determining region (CDR) 1 consisting of SEQ ID NO:
- 22, a CDR 2 consisting of SEQ ID NO:
- 23 and a CDR 3 consisting of SEQ ID NO:
- 24 and a light chain variable region comprising a CDR 1 consisting of SEQ ID NO:
- 25, a CDR 2 consisting of SEQ ID NO:
- 26 and a CDR 3 consisting of SEQ ID NO:
- 27.
Dependencies are inferred from the claim text.