Antibacterial agents: salinamide derivatives
AssigneeRutgers, The State University of New Jersey
InventorsRichard H. Ebright, Yon W. Ebright, Yu Feng, David Degen
Life of this patent
Estimating the term…
Abstract
The invention provides compounds of formula (I): and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.
Claims15
A compound of formula (I):
- wherein:
- X is one of —Br, —I, —OR, —SR, and —NHR;
- Y is one of —Br, —I, —OR, —SR, and —NHR;
- and at least one of X and Y is OH;
- each R is independently H or a branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 3 to 15 carbon atoms, wherein one or more of the carbon atoms is optionally replaced by (—O—) or (—NRa—), and wherein the chain is optionally substituted on carbon with one or more substituents independently selected from the group consisting of (C1-C6)alkoxy, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo, carboxy, aryl, aryloxy, heteroaryl, heteroaryloxy, a hydrogen-bonding group, and a negatively charged functional group;
- and
- each Ra is independently H or (C1-C6)alkyl;
- or a salt thereof.
The compound of claim h which is a compound of formula (Ia):
- or a salt thereof.
The compound of claim h wherein the negatively charged functional group is selected from carboxyl, thiocarboxyl, sulfonic acid, phosphoric acid, phosphoric acid ester, boronic acid, triazole, tetrazole, purine, and thiol, and ionized forms and salts thereof.
The compound selected from the group consisting of:
- and salts thereof.
Dependencies are inferred from the claim text.