2-fluorophenyl propionic acid derivatives
AssigneeLTT Bio-Pharma Co., Ltd.
InventorsToru Mizushima, Masami Otsuka, Yoshinari Okamoto, Naoki Yamakawa
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Abstract
Provided are novel 2-fluorophenyl propionic acid derivatives which have excellent anti-inflammatory/analgesic effects while avoiding side effects such as gastrointestinal disorders, namely 2-fluorophenyl propionic acid derivatives represented by the formula (I) below or pharmaceutically acceptable salts thereof, [wherein, R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents —CH2—, —NH—, —O—, or —S—, and Y specifically represents group (II) (wherein, Z1 represents —CO—, —CH(OH)—, or —CH2—, and n represents an integer of 1 or 2.)]
Claims14
A 2-fluorophenyl propionic acid derivative or a pharmaceutically acceptable salt thereof represented by formula (I-a):
- wherein
- R1 is a hydrogen atom,
- X is —NH— or —O—,
- Z1 is —CH2—, and n is 1.
A 2-fluorophenyl propionic acid derivative or a pharmaceutically acceptable salt thereof represented by formula (I-b):
- wherein
- R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group,
- X represents —CH2—, —NH—, —O—, or —S—, and
- Z2 represents an oxygen atom or a sulfur atom.
A 2-fluorophenyl propionic acid derivative or a pharmaceutically acceptable salt thereof represented by formula (I-c):
- wherein
- R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group,
- X represents —CH2—, —NH—, —O—, or —S—, and
- Z2 represents an oxygen atom or a sulfur atom.
A 2-fluorophenyl propionic acid derivative or a pharmaceutically acceptable salt thereof represented by formula (I-d):
- wherein R1
- represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group,
- X represents —CH2—, —NH—, —O—, or —S—, and
- wherein R2 and R3, which are the same or different, represent a lower alkyl group, and
- wherein R1 does not represent hydrogen atom when X represents —CH2—, respectively.
Dependencies are inferred from the claim text.